Ever since penicillin was accidentally discovered in 1928, numerous antibiotics have been created that have spared millions of lives from immeasurable suffering around the globe. The only problem is bacteria has a knack for developing resistance against antibiotics, and now we have entered an era where many antibiotics that have been depended on for years are now useless. That raises the question: How will we protect against new bacterial threats? The world of computational modeling gives us a clue.