Stress: It may be a good short-term motivator, but prolonged stress can have harsh consequences on your body. Constant stress can lead to a poor immune system, weight gain around the middle, poor sleep quality and low blood pressure. Anything from big life issues to simply being late for work can increase your cortisol levels, one of the main three hormones associated with stress. Here are some simple ways to offset excess cortisol associated with prolonged stress.